陈文连、男、1984年生人，农工民主党党员、研究员、上海中医药大学附属龙华医院基础研究部主任。

2002年9月-2006年7月，东北师范大学，生命科学学院，生物技术，本科

2006年9月-2011年7月，上海交通大学，医学院，遗传学，硕博连读

2011年9月-2014年5月，中国科学院上海生命科学研究院，博士后

2014年5月-2017年4月，美国夏威夷大学癌症中心（University of Hawaii Cancer Center），博士后

2017年4月-至今，上海中医药大学附属龙华医院，研究员 

     （1）拓展“扶正治癌”学术思想之调控代谢重编程扶正的新内涵：健脾补肾是常用的扶正培本治法。我们的研究证实调控代谢重编程是健脾补肾法治疗肿瘤的现代医学新内涵。例如我们发现金复康发挥抗肿瘤活性的代谢靶点为：抑制外周血中的包括乙酰辅酶A在内的促癌代谢物、以及抑制肿瘤内ACLY介导的乙酰辅酶A和脂肪酸合成。

     （2）阐释健脾补肾法治疗肿瘤的物质基础及其作用新机制：发现补肾中药淫羊藿和女贞子共有的活性成分---齐墩果酸通过抑制嘌呤补救合成途径发挥抗肿瘤疗效。还发现益气健脾中药黄芪中黄酮类活性成分---异鼠李素通过抑制ACC1介导的脂肪酸合成发挥抗肿瘤疗效。

    （3）鉴定临床肿瘤患者的关键代谢通路并阐明其促癌机制，为中医药通过干预代谢重编程治疗肿瘤提供科学依据：创新性发现患者肿瘤细胞中存在一条新型能量代谢通路---GLUT5介导的果糖代谢，并阐明其促癌新机制：激活脂肪酸合成和AMPK/mTORC1信号。

1.Xing Jin#, Lei Liu#, Jia Wu#, Xiaoxia Jin, Guanzhen Yu, Lijun Jia, Fengying Wang, Minxin Shi, Haimin Lu, Jibin Liu, Dan Liu, Jing Yang, Hua Li, Yan Ni, Qin Luo, Wei Jia*, Wei Wang*, Wen-Lian Chen*. A multi-omics study delineates new molecular features and therapeutic targets for esophageal squamous cell carcinoma. Clin Transl Med, 2021, 11(9):e538. (Impact factor 11.49). 

2.Dan Liu#, Xing Jin#, Guanzhen Yu, Mingsong Wang, Lei Liu, Wenjuan Zhang, Jia Wu, Fengying Wang, Jing Yang, Qin Luo, Lili Cai, Xi Yang, Xisong Ke, Yi Qu, Zhenye Xu, Lijun Jia*, Wen-Lian Chen*. Oleanolic acid blocks the purine salvage pathway for cancer therapy by inactivating SOD1 and stimulating lysosomal proteolysis. Mol Ther Oncolytics, 2021, 23:107-123. (Impact factor 7.2). 

3.Lei Liu#, Jia Wu#, Minxin Shi#, Fengying Wang, Haimin Lu, Jibing Liu, Weiqin Chen, Guanzhen Yu, Dan Liu, Jing Yang, Qin Luo, Yan Ni, Xing Jin*, Xiaoxia Jin*, Wen-Lian Chen*. New metabolic alterations and predictive marker pipecolic acid in sera for esophageal squamous cell carcinoma. Genomics Proteomics Bioinformatics, 2021, accepted. (Impact factor 7.69). 

4.Weixing Dai#, Ye Xu#, Shaobo Mo#, Qingguo Li#, Jun Yu#, Renjie Wang, Yanlei Ma, Yan Ni, Wenqiang Xiang, Lingyu Han, Long Zhang, Sanjun Cai, Jun Qin*, Wen-Lian Chen*, Wei Jia*, Guoxiang Cai*. GLUT3 induced by AMPK/CREB1 axis is key for withstanding energy stress and augments the efficacy of current colorectal cancer therapies. Signal Transduct Target Ther, 2020,5(1):177. (Impact factor 18.18).

5.Wen-Lian Chen#*, Xing Jin#, Mingsong Wang#, Dan Liu#, Qin Luo, Hechuan Tian, Lili Cai, Lifei Meng, Rui Bi, Lei Wang, Xiao Xie, Guanzhen Yu, Lihui Li, Changsheng Dong, Qiliang Cai, Wei Jia, Wenyi Wei, Lijun Jia*. GLUT5-mediated fructose utilization drives lung cancer growth by stimulating fatty acid synthesis and AMPK/mTORC1 signaling. JCI Insight, 2020, 5(3):e131596. (Impact factor 8.31). 

6.Xing Jin#, Yupei Liang#, Dan Liu, Qin Luo, Lili Cai, Jia Wu, Lijun Jia*, Wen-Lian Chen*. An essential role for GLUT5-mediated fructose utilization in exacerbating the malignancy of clear cell renal cell carcinoma. Cell Biol Toxicol, 2019, 35, (5), 471-483 (Impact factor 6.3). 

7.Wen-Lian Chen#, Yue-Ying Wang#, Aihua Zhao#, Li Xia, Guoxiang Xie, Mingming Su, Linjing Zhao, Jiajian Liu, Chun Qu, Runmin Wei, Cynthia Rajani, Yan Ni, Zhen Cheng, Zhu Chen, Sai-Juan Chen*, and Wei Jia*. Enhanced fructose utilization mediated by SLC2A5 is a unique metabolic feature of acute myeloid leukemia with therapeutic potential. Cancer Cell, 2016, 30 (5):779-791 (Impact factor 27.407). 

8.Wen-Lian Chen#, Jing-Han Wang#, Ai-Hua Zhao#, Xin Xu#, Yi-Huang Wang#, Tian-Lu Chen, Jun-Min Li, Jian-Qing Mi, Yong-Mei Zhu, Yuan-Fang Liu, Yue-Ying Wang, Jie Jin, He Huang, De-Pei Wu, Yan Li, Xiao-Jing Yan, Jin-Song Yan, Jian-Yong Li, Shuai Wang, Xiao-Jun Huang, Bing-Shun Wang, Zhu Chen, Sai-Juan Chen*, and Wei Jia*. A distinct glucose metabolism signature of acute myeloid leukemia with prognostic value. Blood, 2014; 124(10): 1645-1654 (Impact factor 10.452). 

Jiang-Han Wang#, Wen-Lian Chen#, Jun-Min Li, Song-Fang Wu, Tian-Lu Chen, Yong-Mei Zhu, Wei-Na Zhang, Yang Li, Yun-Ping Qiu, Ai-Hua Zhao, Jian-Qing Mi, Jie Jin, Yun-Gui Wang, Qiu-Ling Ma, He Huang, De-Pei Wu, Qin-Rong Wang, Yan Li, Xiao-Jing Yan, Jin-Song Yan, Jian-Yong Li, Shuai Wang, Xiao-Jun Huang, Bing-Shun Wang, Wei Jia*, Yang Shen*, Zhu Chen*, and Sai-Juan Chen*. Prognostic Significance of 2-Hydroxyglutarate Levels in Acute Myeloid Leukemia in China. PNAS, 2013, 110(42): 17017-17022 (Impact factor 9.809).

      入选“上海高校特聘教授（东方学者）”、“上海市青年拔尖人才”、“上海市青年科技启明星”等人才项目。荣获“上海市卫生系统第十七届银蛇奖 二等奖”。